v0.5.2

Sample Data:

Upload Data
Reference Proteome:

Filter the samples

Select a variable to filter:

Identify Subgroup Differences

Investigate Subgroup Differences:

Import/Export Config

Download Config

Welcome!

RokaiXplorer is a tool to perform interactive analysis of phospho-proteomic data.
You can use this tool to identify significant changes in phosphorylation and infer kinase activities using RoKAI.

If you have any suggestions or comments, feel free to give feedback or contact us.
If you would like to impact future developments, please fill a 5-question survey to help us prioritize which additional features to implement next!
* The application is still in development. New features may be added or there may be changes in the way analysis are conducted as time goes on.

Contact

RoKAI is designed by Serhan Yilmaz and Mehmet Koyuturk at Case Western Reserve University.
If you have any questions, please contact <serhan.yilmaz@case.edu>

Giving feedback

To make comments, suggestions or to report a problem, please use the form below:

References

This application uses the following resources:
  • Yilmaz S., Ayati M., Schlatzer D., Cicek A. E., Chance M. R., Koyuturk M. (2021) Robust inference of kinase activity using functional networks Nature Communications 12 (1117)
  • Hornbeck, P. V. et al. (2015) Phosphositeplus, 2014: mutations, ptms and recalibrations. Nucleic acids research 43(D1), D512-D520
  • Licata, L. et al. (2020) SIGNOR 2.0, the SIGnaling network open resource 2.0: 2019 update. Nucleic acids research 48(D1), D504-D510
  • Minguez, P. et al. (2012) PTMcode: a database of known and predicted functional associations between post-translational modifications in proteins. Nucleic acids research 41(D1), D306-D311
  • Szklarczyk, D. et al. (2014) STRING v10: protein–protein interaction networks, integrated over the tree of life. Nucleic acids research 43(D1), D447-D452
  • Damle, N. P., & Köhn, M. (2019) The human DEPhOsphorylation Database DEPOD: 2019 update. Database
Click on a point to inspect it in detail.
Significant sites only
Plot Y-Axis:
Coloring:
Significant sites only
Show:
Double click on a row to inspect it in detail.
Significant sites only
Single Kinases
Click on a point to inspect it in detail.
Significant proteins only
Plot Y-Axis:
Coloring:
Significant proteins only
Show:
Double click on a row to inspect it in detail.
Significant proteins only
Single Kinases
Click on a point to inspect it in detail.
Significant kinases only
Plot Y-Axis:
Coloring:
Significant kinases only
Show:
Double click on a row to inspect it in detail.
Double click on a row to inspect it in detail.